منابع مشابه
Potential Role of Patients’ CYP3A-Status in Clozapine Pharmacokinetics
Background The atypical antipsychotic clozapine is effective in treatment-resistant schizophrenia; however, the success or failure of clozapine therapy is substantially affected by the variables that impact the clozapine blood concentration. Thus, elucidating the inter-individual differences in clozapine pharmacokinetics can facilitate the personalized therapy. Methods Since a potential role ...
متن کاملIndividual Differences in The Pharmacokinetics of Clozapine in Healthy Chinese Adults
Introduction: Differences in response to clozapine among patients have received considerable attention. Individual pharmacokinetic differences are a major reason. Objective: The aim of this study was to investigate the pharmacokinetic variability in the blood levels ofclozapine among young, healthy, Chinese male volunteers. Methods: A total of 18 volunteers who received 12.5mg of clozapine part...
متن کاملMicrodialysis evaluation of clozapine and N-desmethylclozapine pharmacokinetics in rat brain.
A significant barrier to realization of the full potential of clozapine as a therapeutic agent in the treatment of schizophrenia is the substantial interpatient variability that exists along the therapeutic continuum of no response-efficacious response-adverse response. Genetic polymorphisms that manifest as highly variable pharmacodynamic and pharmacokinetic measures are its expected causes. T...
متن کاملSteady-State Clozapine and Norclozapine Pharmacokinetics in Maori and European Patients
BACKGROUND Clozapine is the most effective drug for treatment-resistant schizophrenia, but its use is limited by toxicity. Because ethnicity has been reported to affect clozapine metabolism, we compared its steady state pharmacokinetics in New Zealand Maori and European patients. METHODS Clozapine and norclozapine steady state bioavailability was assessed over 24h under fasting and fed condit...
متن کاملClozapine rechallenge following clozapine-induced pericarditis.
To the Editor: There are many reports describing the development of myocarditis and cardiomyopathy following treatment with clozapine. Fewer reports exist about the development of pericarditis, and reports of successful rechallenges with clozapine following the development of pericarditis are particularly rare. We report the case of a patient successfully resumed on clozapine treatment followin...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 1999
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.175.3.288a